Age 40 for men at even higher risk (those with more than one first-degree relative who had prostate cancer at an early age). After this discussion, men who want to be screened should get the prostate-specific antigen (PSA) blood test. The digital rectal exam (DRE) may also be done as a part of screening. (See Screening Tests for Prostate Cancer.) Age (years) Serum PSA reference range ng/ml. 40 - 49. 0 - 2.5. 50 - 59. 0 - 3.5. 60 - 69. 0 - 4.5. 70 - 79. Prostate-specific antigen (PSA) is a glycoprotein produced by the prostate gland, the lining of the urethra, and the bulbourethral gland. The total PSA range of 4.0 to 10.0 ng/mL has been described as a diagnostic "gray zone," in which the free PSA:total PSA ratio helps to determine the relative risk of prostate cancer (see table A new report in the British medical journal BMJ might help simplify decision-making. It suggests that a single PSA measurement at age 60 can predict the likelihood that a man will die of prostate cancer by age 85, and that at least half of men no longer need to be screened after age 60. Researchers from Memorial Sloan-Kettering Cancer Center in The range generally accepted as a "normal" PSA level spans from zero to four nanograms of PSA per milliliter of blood, though there are exceptions based on age, race, and risk factors. You and your physician can discuss whether any such nuanced situations apply to you. PSA values by age. PSA values increase with age. The fact that PSA measurements are within these values does not mean that there is no cancer. A prostate examination should also be done. PSA values according to certain age ranges are as follows; 0-2.5 ng/ml between the ages of 40-49; 0-3.5 ng/ml between 50-59 years old Search strategy. PubMed and Embase were searched on the 24 th September 2021 and again on the 21 st June 2022 to identify studies that reported levels of PSA for at least two ethnic groups. Search harm-benefit profile of PSA-based prostate cancer screening is highly age dependent, guideline statements included in this document target four index patients; these age ranges were chosen to correspond to age ranges tested in randomized trials and data from population and simulation studies. Four Index Patients 1. Men <40 years of age 2. During a PSA test, a small amount of blood is drawn from the arm, and the level of PSA, a protein produced by the prostate, is measured. A higher PSA means that there is a greater chance that you have prostate cancer. Historically, a PSA of 3 or 4 was considered as the threshold of "normal" vs "abnormal.". However, we now know that it PSA levels are measured in nanograms per milliliter (ng/mL), and a normal range typically falls between 0 and 4 ng/mL. It's essential to keep in mind that various factors can influence PSA levels, and individual baselines may vary. Age, ethnicity, and health play roles in determining what is considered a normal PSA level for an individual. qZ8EV.